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Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]

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Diabetologia 62 (9), 15391549

In one study of 208 patients, 45 experienced 88 fractures, with Standardized Incidence Ratios (SIRs) of 2.9 in females and 3.4 in males

As a result, this approach improves the bioavailability of oral supplemental B12, providing a more reliable source of the nutrient